:root{--color-bg:#e7edf5;--color-surface:#eef2f8;--color-surface-raised:#f3f6fb;--color-primary:#2f5fac;--color-primary-contrast:#fff;--color-accent:#3d7a68;--color-text:#17202b;--color-text-muted:#4b5a70;--color-border:#c7d2e3;--color-danger-bg:#fbe9e9;--color-danger-text:#7a1f1f;--color-success-text:#1f6b4a;--radius-lg:22px;--radius-md:14px;--radius-sm:9px;--shadow-convex-outer:9px 9px 18px #a3b1c68c, -9px -9px 18px #ffffffd9;--shadow-convex-outer-sm:4px 4px 9px #a3b1c680, -4px -4px 9px #fffc;--shadow-concave-inset:inset 4px 4px 9px #a3b1c673, inset -4px -4px 9px #ffffffb3;--font-sans:"Inter", "Segoe UI", system-ui, -apple-system, sans-serif}body{background:var(--color-bg);color:var(--color-text)}@media (prefers-color-scheme:dark){:root:not([data-theme=light]){--color-bg:#151b24;--color-surface:#1b222d;--color-surface-raised:#202836;--color-primary:#7fa9e8;--color-primary-contrast:#0b1220;--color-accent:#6fc0a4;--color-text:#eef2f8;--color-text-muted:#a7b4c8;--color-border:#313e50;--color-danger-bg:#3a2020;--color-danger-text:#f3b4b4;--color-success-text:#8fd9b8;--shadow-convex-outer:9px 9px 18px #0000008c, -9px -9px 18px #ffffff0a;--shadow-convex-outer-sm:4px 4px 9px #00000080, -4px -4px 9px #ffffff0a;--shadow-concave-inset:inset 4px 4px 9px #00000080, inset -4px -4px 9px #ffffff0a}}:root[data-theme=dark]{--color-bg:#151b24;--color-surface:#1b222d;--color-surface-raised:#202836;--color-primary:#7fa9e8;--color-primary-contrast:#0b1220;--color-accent:#6fc0a4;--color-text:#eef2f8;--color-text-muted:#a7b4c8;--color-border:#313e50;--color-danger-bg:#3a2020;--color-danger-text:#f3b4b4;--color-success-text:#8fd9b8;--shadow-convex-outer:9px 9px 18px #0000008c, -9px -9px 18px #ffffff0a;--shadow-convex-outer-sm:4px 4px 9px #00000080, -4px -4px 9px #ffffff0a;--shadow-concave-inset:inset 4px 4px 9px #00000080, inset -4px -4px 9px #ffffff0a}:root[data-theme=light]{--color-bg:#e7edf5;--color-surface:#eef2f8;--color-surface-raised:#f3f6fb;--color-primary:#2f5fac;--color-primary-contrast:#fff;--color-accent:#3d7a68;--color-text:#17202b;--color-text-muted:#4b5a70;--color-border:#c7d2e3;--color-danger-bg:#fbe9e9;--color-danger-text:#7a1f1f;--color-success-text:#1f6b4a;--shadow-convex-outer:9px 9px 18px #a3b1c68c, -9px -9px 18px #ffffffd9;--shadow-convex-outer-sm:4px 4px 9px #a3b1c680, -4px -4px 9px #fffc;--shadow-concave-inset:inset 4px 4px 9px #a3b1c673, inset -4px -4px 9px #ffffffb3}html,body,#root{min-height:100vh;font-family:var(--font-sans);margin:0}.ngx-app{flex-direction:column;min-height:100vh;display:flex}.ngx-card{background:var(--color-surface-raised);border-radius:var(--radius-lg);box-shadow:var(--shadow-convex-outer);padding:24px}.ngx-card-sm{border-radius:var(--radius-md);box-shadow:var(--shadow-convex-outer-sm);padding:16px}.ngx-btn{font-family:var(--font-sans);border-radius:var(--radius-md);cursor:pointer;box-shadow:var(--shadow-convex-outer-sm);border:none;padding:10px 20px;font-size:.95rem;font-weight:600;transition:box-shadow .12s,transform .12s}.ngx-btn:active{box-shadow:var(--shadow-concave-inset);transform:translateY(1px)}.ngx-btn:disabled{opacity:.55;cursor:not-allowed}.ngx-btn-primary{background:var(--color-primary);color:var(--color-primary-contrast)}.ngx-btn-secondary{background:var(--color-surface-raised);color:var(--color-text)}.ngx-btn-danger{background:var(--color-danger-bg);color:var(--color-danger-text)}.ngx-input,.ngx-select{font-family:var(--font-sans);color:var(--color-text);background:var(--color-surface);border:1px solid var(--color-border);border-radius:var(--radius-sm);box-shadow:var(--shadow-concave-inset);padding:9px 12px;font-size:.95rem}.ngx-input:focus,.ngx-select:focus{outline:2px solid var(--color-primary);outline-offset:1px}.ngx-label{color:var(--color-text-muted);margin-bottom:6px;font-size:.85rem;font-weight:600;display:block}.ngx-banner{background:var(--color-danger-bg);color:var(--color-danger-text);text-align:center;z-index:50;padding:8px 16px;font-size:.85rem;font-weight:600;position:sticky;top:0}.ngx-layout{flex:1;display:flex}.ngx-nav{background:var(--color-surface);width:220px;box-shadow:var(--shadow-convex-outer-sm);border-radius:0 var(--radius-lg) var(--radius-lg) 0;flex-direction:column;flex-shrink:0;gap:6px;padding:20px 12px;display:flex}.ngx-nav-link{border-radius:var(--radius-sm);color:var(--color-text);padding:10px 14px;font-size:.92rem;font-weight:600;text-decoration:none;display:block}.ngx-nav-link:hover{box-shadow:var(--shadow-convex-outer-sm)}.ngx-nav-link.active{background:var(--color-primary);color:var(--color-primary-contrast)}.ngx-main{flex:1;max-width:1100px;padding:28px 32px}.ngx-footer{text-align:center;color:var(--color-text-muted);border-top:1px solid var(--color-border);padding:18px;font-size:.8rem}.ngx-h1{margin:0 0 4px;font-size:1.6rem;font-weight:700}.ngx-h2{margin:0 0 12px;font-size:1.15rem;font-weight:700}.ngx-subtitle{color:var(--color-text-muted);margin:0 0 20px}.ngx-grid{grid-template-columns:repeat(auto-fit,minmax(220px,1fr));gap:18px;display:grid}.ngx-stack{flex-direction:column;gap:16px;display:flex}.ngx-row{flex-wrap:wrap;align-items:flex-end;gap:12px;display:flex}.ngx-table{border-collapse:collapse;width:100%;font-size:.9rem}.ngx-table th,.ngx-table td{text-align:left;border-bottom:1px solid var(--color-border);padding:8px 10px}.ngx-table th{color:var(--color-text-muted);text-transform:uppercase;letter-spacing:.03em;font-size:.8rem;font-weight:600}.ngx-pill{letter-spacing:.03em;border-radius:999px;padding:3px 9px;font-size:.72rem;font-weight:700;display:inline-block}.ngx-pill-curated{background:var(--color-surface);color:var(--color-primary);box-shadow:var(--shadow-convex-outer-sm)}.ngx-pill-simulated{background:var(--color-surface);color:var(--color-accent);box-shadow:var(--shadow-convex-outer-sm)}.ngx-pill-verified{background:var(--color-surface);color:var(--color-success-text);box-shadow:var(--shadow-convex-outer-sm)}.ngx-pill-status-pending,.ngx-pill-status-running{background:var(--color-surface);color:var(--color-text-muted);box-shadow:var(--shadow-convex-outer-sm)}.ngx-pill-status-done{background:var(--color-surface);color:var(--color-success-text);box-shadow:var(--shadow-convex-outer-sm)}.ngx-pill-status-failed,.ngx-pill-unverified{background:var(--color-surface);color:var(--color-danger-text);box-shadow:var(--shadow-convex-outer-sm)}.ngx-success-text{color:var(--color-success-text);font-weight:600}.ngx-error{color:var(--color-danger-text);background:var(--color-danger-bg);border-radius:var(--radius-sm);padding:10px 14px;font-size:.88rem}.ngx-topbar{background:var(--color-surface);justify-content:space-between;align-items:center;padding:14px 24px;display:flex}.ngx-brand{color:var(--color-primary);font-size:1.05rem;font-weight:800}.ngx-tabs{flex-wrap:wrap;gap:8px;display:flex}.ngx-tab{font-family:var(--font-sans);background:var(--color-surface);color:var(--color-text-muted);border-radius:var(--radius-md);cursor:pointer;box-shadow:var(--shadow-convex-outer-sm);border:none;padding:9px 18px;font-size:.9rem;font-weight:600;transition:box-shadow .12s}.ngx-tab.active{background:var(--color-primary);color:var(--color-primary-contrast)}.ngx-link{color:var(--color-primary);font-weight:600;text-decoration:none}.ngx-link:hover{text-decoration:underline}.ngx-cell-wrap{white-space:normal;max-width:300px;color:var(--color-text-muted)}.ngx-pathway-grid{grid-template-columns:repeat(auto-fit,minmax(240px,1fr));gap:16px;display:grid}.ngx-pathway-node{background:var(--color-surface-raised);border-radius:var(--radius-lg);box-shadow:var(--shadow-convex-outer-sm);border-left:4px solid var(--color-border);padding:16px}.ngx-pathway-node.in-disease{border-left-color:var(--color-accent)}.ngx-empty{color:var(--color-text-muted);font-style:italic}*{box-sizing:border-box}body{min-height:100vh;margin:0}#root{min-height:100vh}